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Mutation:
TP53 P151S
Summary
Isoform:
Position:
151
Ref:
P
Mutation:
S
PTM impact:
network-rewiring
PTM affected:
3
Kinases:
CSNK2A1,
CSNK2A1,
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
UCEC, HNSC, LGG, READ, UCS, ESCA, SARC, BLCA
Cancer types: (PCAWG)
Ovary-AdenoCA, Uterus-AdenoCA, Eso-AdenoCa, Breast-AdenoCa
Disease Annotations: (ClinVar)
Hereditary cancer-predisposing syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 149S
Affected site:
Position: 149
Residue: S
Type: O-glycosylation, phosphorylation
Impact:
proximalOther known mutations affecting this site
PTM Site: 150T
Affected site:
Position: 150
Residue: T
Type: phosphorylation
Best loss of PTM site:
MAPK3 (probability p=0.94)
Site: 150T (phosphorylation)
Position in motif: 1
There are 3 other predicted
losses:
- CDK1 (p=0.921)
- MAPK1 (p=0.92)
- GSK3B (p=0.887)
Other known mutations affecting this site
PTM Site: 155T
Affected site:
Position: 155
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
External references
dbSNP:
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