TP53 G154S

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Mutation:

Summary

Isoform:

NM_000546

Position:

154

Ref:

Mutation:

PTM impact:

proximal

PTM affected:

Kinases:

CSNK2A1, CSNK2A1, CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Li-Fraumeni syndrome, Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 149S

Affected site:

Position: 149

Residue: S

Type: phosphorylation, O-glycosylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
155S	PVQLWVDSTPPPG[T/S]TR	6	distal
155N	PVQLWVDSTPPPG[T/N]TR	6	distal
155A	PVQLWVDSTPPPG[T/A]TR	6	distal
154V	PVQLWVDSTPPP[G/V]GTR	5	distal
154D	PVQLWVDSTPPP[G/D]GTR	5	distal
154R	PVQLWVDSTPPP[G/R]GTR	5	distal
154S	PVQLWVDSTPPP[G/S]GTR	5	distal
153L	PVQLWVDSTPP[P/L]PGTR	4	distal
153S	PVQLWVDSTPP[P/S]PGTR	4	network-rewiring
152L	PVQLWVDSTP[P/L]PPGTR	3	distal
152R	PVQLWVDSTP[P/R]PPGTR	3	distal
152S	PVQLWVDSTP[P/S]PPGTR	3	distal
151R	PVQLWVDST[P/R]PPPGTR	2	network-rewiring
151H	PVQLWVDST[P/H]PPPGTR	2	proximal
151S	PVQLWVDST[P/S]PPPGTR	2	proximal
151A	PVQLWVDST[P/A]PPPGTR	2	proximal
151T	PVQLWVDST[P/T]PPPGTR	2	proximal
149F	PVQLWVD[S/F]STPPPGTR	0	direct
148A	PVQLWV[D/A]DSTPPPGTR	1	proximal
148Y	PVQLWV[D/Y]DSTPPPGTR	1	proximal
148N	PVQLWV[D/N]DSTPPPGTR	1	proximal
147A	PVQLW[V/A]VDSTPPPGTR	2	proximal
147I	PVQLW[V/I]VDSTPPPGTR	2	proximal
146C	PVQL[W/C]WVDSTPPPGTR	3	distal
146G	PVQL[W/G]WVDSTPPPGTR	3	distal
145P	PVQ[L/P]LWVDSTPPPGTR	4	distal
145Q	PVQ[L/Q]LWVDSTPPPGTR	4	distal
144H	PV[Q/H]QLWVDSTPPPGTR	5	distal
144L	PV[Q/L]QLWVDSTPPPGTR	5	distal
144P	PV[Q/P]QLWVDSTPPPGTR	5	distal
143G	P[V/G]VQLWVDSTPPPGTR	6	distal
143A	P[V/A]VQLWVDSTPPPGTR	6	distal
143L	P[V/L]VQLWVDSTPPPGTR	6	distal
143M	P[V/M]VQLWVDSTPPPGTR	6	distal
155I	PVQLWVDSTPPPG[T/I]TR	6	distal
155P	PVQLWVDSTPPPG[T/P]TR	6	distal
143E	P[V/E]VQLWVDSTPPPGTR	6	distal
152Q	PVQLWVDSTP[P/Q]PPGTR	3	distal
145R	PVQ[L/R]LWVDSTPPPGTR	4	distal
146S	PVQL[W/S]WVDSTPPPGTR	3	distal

PTM Site: 150T

Affected site:

Position: 150

Residue: T

Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
156P	VQLWVDSTPPPGT[R/P]RV	6	distal
156H	VQLWVDSTPPPGT[R/H]RV	6	distal
156C	VQLWVDSTPPPGT[R/C]RV	6	distal
155S	VQLWVDSTPPPG[T/S]TRV	5	distal
155N	VQLWVDSTPPPG[T/N]TRV	5	distal
155A	VQLWVDSTPPPG[T/A]TRV	5	distal
154V	VQLWVDSTPPP[G/V]GTRV	4	distal
154D	VQLWVDSTPPP[G/D]GTRV	4	distal
154R	VQLWVDSTPPP[G/R]GTRV	4	distal
154S	VQLWVDSTPPP[G/S]GTRV	4	distal
153L	VQLWVDSTPP[P/L]PGTRV	3	distal
153S	VQLWVDSTPP[P/S]PGTRV	3	distal
152L	VQLWVDSTP[P/L]PPGTRV	2	proximal
152R	VQLWVDSTP[P/R]PPGTRV	2	network-rewiring
152S	VQLWVDSTP[P/S]PPGTRV	2	proximal
151R	VQLWVDST[P/R]PPPGTRV	1	network-rewiring
151H	VQLWVDST[P/H]PPPGTRV	1	network-rewiring
151S	VQLWVDST[P/S]PPPGTRV	1	network-rewiring
151A	VQLWVDST[P/A]PPPGTRV	1	network-rewiring
151T	VQLWVDST[P/T]PPPGTRV	1	network-rewiring
149F	VQLWVD[S/F]STPPPGTRV	1	proximal
148A	VQLWV[D/A]DSTPPPGTRV	2	proximal
148Y	VQLWV[D/Y]DSTPPPGTRV	2	proximal
148N	VQLWV[D/N]DSTPPPGTRV	2	proximal
147A	VQLW[V/A]VDSTPPPGTRV	3	distal
147I	VQLW[V/I]VDSTPPPGTRV	3	distal
146C	VQL[W/C]WVDSTPPPGTRV	4	distal
146G	VQL[W/G]WVDSTPPPGTRV	4	distal
145P	VQ[L/P]LWVDSTPPPGTRV	5	distal
145Q	VQ[L/Q]LWVDSTPPPGTRV	5	distal
144H	V[Q/H]QLWVDSTPPPGTRV	6	distal
144L	V[Q/L]QLWVDSTPPPGTRV	6	distal
144P	V[Q/P]QLWVDSTPPPGTRV	6	distal
155I	VQLWVDSTPPPG[T/I]TRV	5	distal
155P	VQLWVDSTPPPG[T/P]TRV	5	distal
156G	VQLWVDSTPPPGT[R/G]RV	6	distal
152Q	VQLWVDSTP[P/Q]PPGTRV	2	proximal
145R	VQ[L/R]LWVDSTPPPGTRV	5	distal
146S	VQL[W/S]WVDSTPPPGTRV	4	distal

PTM Site: 155T

Affected site:

Position: 155

Residue: T

Type: phosphorylation

Impact:

proximal

Other known mutations affecting this site

Mutation	In sequence	Distance	Impact
161D	DSTPPPGTRVRAM[A/D]AI	6	distal
161T	DSTPPPGTRVRAM[A/T]AI	6	distal
159V	DSTPPPGTRVR[A/V]AMAI	4	distal
159P	DSTPPPGTRVR[A/P]AMAI	4	distal
158L	DSTPPPGTRV[R/L]RAMAI	3	distal
158P	DSTPPPGTRV[R/P]RAMAI	3	distal
158H	DSTPPPGTRV[R/H]RAMAI	3	distal
158C	DSTPPPGTRV[R/C]RAMAI	3	distal
158G	DSTPPPGTRV[R/G]RAMAI	3	distal
157G	DSTPPPGTR[V/G]VRAMAI	2	proximal
157A	DSTPPPGTR[V/A]VRAMAI	2	proximal
157D	DSTPPPGTR[V/D]VRAMAI	2	proximal
157F	DSTPPPGTR[V/F]VRAMAI	2	proximal
157I	DSTPPPGTR[V/I]VRAMAI	2	proximal
156P	DSTPPPGT[R/P]RVRAMAI	1	network-rewiring
156H	DSTPPPGT[R/H]RVRAMAI	1	proximal
156C	DSTPPPGT[R/C]RVRAMAI	1	proximal
155S	DSTPPPG[T/S]TRVRAMAI	0	direct
155N	DSTPPPG[T/N]TRVRAMAI	0	direct
155A	DSTPPPG[T/A]TRVRAMAI	0	direct
154V	DSTPPP[G/V]GTRVRAMAI	1	proximal
154D	DSTPPP[G/D]GTRVRAMAI	1	proximal
154R	DSTPPP[G/R]GTRVRAMAI	1	proximal
154S	DSTPPP[G/S]GTRVRAMAI	1	proximal
153L	DSTPP[P/L]PGTRVRAMAI	2	proximal
153S	DSTPP[P/S]PGTRVRAMAI	2	proximal
152L	DSTP[P/L]PPGTRVRAMAI	3	distal
152R	DSTP[P/R]PPGTRVRAMAI	3	network-rewiring
152S	DSTP[P/S]PPGTRVRAMAI	3	distal
151R	DST[P/R]PPPGTRVRAMAI	4	distal
151H	DST[P/H]PPPGTRVRAMAI	4	distal
151S	DST[P/S]PPPGTRVRAMAI	4	distal
151A	DST[P/A]PPPGTRVRAMAI	4	distal
151T	DST[P/T]PPPGTRVRAMAI	4	distal
149F	D[S/F]STPPPGTRVRAMAI	6	distal
155I	DSTPPPG[T/I]TRVRAMAI	0	direct
155P	DSTPPPG[T/P]TRVRAMAI	0	direct
156G	DSTPPPGT[R/G]RVRAMAI	1	proximal
157L	DSTPPPGTR[V/L]VRAMAI	2	proximal
161V	DSTPPPGTRVRAM[A/V]AI	6	distal
152Q	DSTP[P/Q]PPGTRVRAMAI	3	distal
161S	DSTPPPGTRVRAM[A/S]AI	6	distal
160I	DSTPPPGTRVRA[M/I]MAI	5	distal
161P	DSTPPPGTRVRAM[A/P]AI	6	distal
158S	DSTPPPGTRV[R/S]RAMAI	3	network-rewiring

External references

dbSNP:

rs137852789

If you have any questions or feedback about this mutation: