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Mutation:

TP53 W146C

Summary

Isoform:
NM_000546
Position:
146
Ref:
W
Mutation:
C
PTM impact:
distal
PTM affected:
3
Kinases:
CSNK2A1, CSNK2A1

Clinical Information

Cancer types: (TCGA MC3)

no data

Cancer types: (PCAWG)

no data

Disease Annotations: (ClinVar)

Hereditary cancer-predisposing syndrome

Minor Allele Frequency: (ESP6500)

no data

Minor Allele Frequency: (1000 Genomes)

no data

PTM Site: 139K

Affected site:

Position: 139
Residue: K
Type: ubiquitination

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
145P KMFCQLAKTCPVQ[L/P]LW 6
distal
145Q KMFCQLAKTCPVQ[L/Q]LW 6
distal
144H KMFCQLAKTCPV[Q/H]QLW 5
distal
144L KMFCQLAKTCPV[Q/L]QLW 5
distal
144P KMFCQLAKTCPV[Q/P]QLW 5
distal
143G KMFCQLAKTCP[V/G]VQLW 4
distal
143A KMFCQLAKTCP[V/A]VQLW 4
distal
143L KMFCQLAKTCP[V/L]VQLW 4
distal
143M KMFCQLAKTCP[V/M]VQLW 4
distal
142L KMFCQLAKTC[P/L]PVQLW 3
distal
142S KMFCQLAKTC[P/S]PVQLW 3
distal
141W KMFCQLAKT[C/W]CPVQLW 2
proximal
141F KMFCQLAKT[C/F]CPVQLW 2
proximal
141Y KMFCQLAKT[C/Y]CPVQLW 2
proximal
141G KMFCQLAKT[C/G]CPVQLW 2
proximal
141R KMFCQLAKT[C/R]CPVQLW 2
proximal
140N KMFCQLAK[T/N]TCPVQLW 1
proximal
140A KMFCQLAK[T/A]TCPVQLW 1
proximal
139N KMFCQLA[K/N]KTCPVQLW 0
direct
139E KMFCQLA[K/E]KTCPVQLW 0
direct
138V KMFCQL[A/V]AKTCPVQLW 1
proximal
138D KMFCQL[A/D]AKTCPVQLW 1
proximal
138P KMFCQL[A/P]AKTCPVQLW 1
proximal
136H KMFC[Q/H]QLAKTCPVQLW 3
distal
136P KMFC[Q/P]QLAKTCPVQLW 3
distal
136E KMFC[Q/E]QLAKTCPVQLW 3
distal
135W KMF[C/W]CQLAKTCPVQLW 4
distal
135F KMF[C/F]CQLAKTCPVQLW 4
distal
135Y KMF[C/Y]CQLAKTCPVQLW 4
distal
135G KMF[C/G]CQLAKTCPVQLW 4
distal
135R KMF[C/R]CQLAKTCPVQLW 4
distal
135S KMF[C/S]CQLAKTCPVQLW 4
distal
134C KM[F/C]FCQLAKTCPVQLW 5
distal
134L KM[F/L]FCQLAKTCPVQLW 5
distal
134I KM[F/I]FCQLAKTCPVQLW 5
distal
143E KMFCQLAKTCP[V/E]VQLW 4
distal
138T KMFCQL[A/T]AKTCPVQLW 1
proximal
133K K[M/K]MFCQLAKTCPVQLW 6
distal
145R KMFCQLAKTCPVQ[L/R]LW 6
distal
134V KM[F/V]FCQLAKTCPVQLW 5
distal
137Q KMFCQ[L/Q]LAKTCPVQLW 2
proximal
133R K[M/R]MFCQLAKTCPVQLW 6
distal

PTM Site: 149S

Affected site:

Position: 149
Residue: S
Type: O-glycosylation, phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
155S PVQLWVDSTPPPG[T/S]TR 6
distal
155N PVQLWVDSTPPPG[T/N]TR 6
distal
155A PVQLWVDSTPPPG[T/A]TR 6
distal
154V PVQLWVDSTPPP[G/V]GTR 5
distal
154D PVQLWVDSTPPP[G/D]GTR 5
distal
154R PVQLWVDSTPPP[G/R]GTR 5
distal
154S PVQLWVDSTPPP[G/S]GTR 5
distal
153L PVQLWVDSTPP[P/L]PGTR 4
distal
153S PVQLWVDSTPP[P/S]PGTR 4
network-rewiring
152L PVQLWVDSTP[P/L]PPGTR 3
distal
152R PVQLWVDSTP[P/R]PPGTR 3
distal
152S PVQLWVDSTP[P/S]PPGTR 3
distal
151R PVQLWVDST[P/R]PPPGTR 2
network-rewiring
151H PVQLWVDST[P/H]PPPGTR 2
proximal
151S PVQLWVDST[P/S]PPPGTR 2
proximal
151A PVQLWVDST[P/A]PPPGTR 2
proximal
151T PVQLWVDST[P/T]PPPGTR 2
proximal
149F PVQLWVD[S/F]STPPPGTR 0
direct
148A PVQLWV[D/A]DSTPPPGTR 1
proximal
148Y PVQLWV[D/Y]DSTPPPGTR 1
proximal
148N PVQLWV[D/N]DSTPPPGTR 1
proximal
147A PVQLW[V/A]VDSTPPPGTR 2
proximal
147I PVQLW[V/I]VDSTPPPGTR 2
proximal
146C PVQL[W/C]WVDSTPPPGTR 3
distal
146G PVQL[W/G]WVDSTPPPGTR 3
distal
145P PVQ[L/P]LWVDSTPPPGTR 4
distal
145Q PVQ[L/Q]LWVDSTPPPGTR 4
distal
144H PV[Q/H]QLWVDSTPPPGTR 5
distal
144L PV[Q/L]QLWVDSTPPPGTR 5
distal
144P PV[Q/P]QLWVDSTPPPGTR 5
distal
143G P[V/G]VQLWVDSTPPPGTR 6
distal
143A P[V/A]VQLWVDSTPPPGTR 6
distal
143L P[V/L]VQLWVDSTPPPGTR 6
distal
143M P[V/M]VQLWVDSTPPPGTR 6
distal
155I PVQLWVDSTPPPG[T/I]TR 6
distal
155P PVQLWVDSTPPPG[T/P]TR 6
distal
143E P[V/E]VQLWVDSTPPPGTR 6
distal
152Q PVQLWVDSTP[P/Q]PPGTR 3
distal
145R PVQ[L/R]LWVDSTPPPGTR 4
distal
146S PVQL[W/S]WVDSTPPPGTR 3
distal

PTM Site: 150T

Affected site:

Position: 150
Residue: T
Type: phosphorylation

Impact:

distal

Other known mutations affecting this site

Mutation In sequence Distance Impact
156P VQLWVDSTPPPGT[R/P]RV 6
distal
156H VQLWVDSTPPPGT[R/H]RV 6
distal
156C VQLWVDSTPPPGT[R/C]RV 6
distal
155S VQLWVDSTPPPG[T/S]TRV 5
distal
155N VQLWVDSTPPPG[T/N]TRV 5
distal
155A VQLWVDSTPPPG[T/A]TRV 5
distal
154V VQLWVDSTPPP[G/V]GTRV 4
distal
154D VQLWVDSTPPP[G/D]GTRV 4
distal
154R VQLWVDSTPPP[G/R]GTRV 4
distal
154S VQLWVDSTPPP[G/S]GTRV 4
distal
153L VQLWVDSTPP[P/L]PGTRV 3
distal
153S VQLWVDSTPP[P/S]PGTRV 3
distal
152L VQLWVDSTP[P/L]PPGTRV 2
proximal
152R VQLWVDSTP[P/R]PPGTRV 2
network-rewiring
152S VQLWVDSTP[P/S]PPGTRV 2
proximal
151R VQLWVDST[P/R]PPPGTRV 1
network-rewiring
151H VQLWVDST[P/H]PPPGTRV 1
network-rewiring
151S VQLWVDST[P/S]PPPGTRV 1
network-rewiring
151A VQLWVDST[P/A]PPPGTRV 1
network-rewiring
151T VQLWVDST[P/T]PPPGTRV 1
network-rewiring
149F VQLWVD[S/F]STPPPGTRV 1
proximal
148A VQLWV[D/A]DSTPPPGTRV 2
proximal
148Y VQLWV[D/Y]DSTPPPGTRV 2
proximal
148N VQLWV[D/N]DSTPPPGTRV 2
proximal
147A VQLW[V/A]VDSTPPPGTRV 3
distal
147I VQLW[V/I]VDSTPPPGTRV 3
distal
146C VQL[W/C]WVDSTPPPGTRV 4
distal
146G VQL[W/G]WVDSTPPPGTRV 4
distal
145P VQ[L/P]LWVDSTPPPGTRV 5
distal
145Q VQ[L/Q]LWVDSTPPPGTRV 5
distal
144H V[Q/H]QLWVDSTPPPGTRV 6
distal
144L V[Q/L]QLWVDSTPPPGTRV 6
distal
144P V[Q/P]QLWVDSTPPPGTRV 6
distal
155I VQLWVDSTPPPG[T/I]TRV 5
distal
155P VQLWVDSTPPPG[T/P]TRV 5
distal
156G VQLWVDSTPPPGT[R/G]RV 6
distal
152Q VQLWVDSTP[P/Q]PPGTRV 2
proximal
145R VQ[L/R]LWVDSTPPPGTRV 5
distal
146S VQL[W/S]WVDSTPPPGTRV 4
distal

External references

dbSNP:
rs1131691026

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