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Mutation:
TP53 T155A
Summary
Isoform:
Position:
155
Ref:
T
Mutation:
A
PTM impact:
direct
PTM affected:
3
Kinases:
CSNK2A1,
CSNK2A1,
CSNK2A1
Clinical Information
Cancer types: (TCGA MC3)
no data
Cancer types: (PCAWG)
no data
Disease Annotations: (ClinVar)
Li-Fraumeni syndrome
Minor Allele Frequency: (ESP6500)
no data
Minor Allele Frequency: (1000 Genomes)
no data
PTM Site: 149S
Affected site:
Position: 149
Residue: S
Type: O-glycosylation, phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 149F | PVQLWVD[S/F]STPPPGTR | 0 |
direct
|
| 148A | PVQLWV[D/A]DSTPPPGTR | 1 |
proximal
|
| 148Y | PVQLWV[D/Y]DSTPPPGTR | 1 |
proximal
|
| 148N | PVQLWV[D/N]DSTPPPGTR | 1 |
proximal
|
| 151R | PVQLWVDST[P/R]PPPGTR | 2 |
network-rewiring
|
PTM Site: 150T
Affected site:
Position: 150
Residue: T
Type: phosphorylation
Impact:
distalOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 151R | VQLWVDST[P/R]PPPGTRV | 1 |
network-rewiring
|
| 151H | VQLWVDST[P/H]PPPGTRV | 1 |
network-rewiring
|
| 151S | VQLWVDST[P/S]PPPGTRV | 1 |
network-rewiring
|
| 151A | VQLWVDST[P/A]PPPGTRV | 1 |
network-rewiring
|
| 151T | VQLWVDST[P/T]PPPGTRV | 1 |
network-rewiring
|
PTM Site: 155T
Affected site:
Position: 155
Residue: T
Type: phosphorylation
Impact:
directOther known mutations affecting this site
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Mutation | In sequence | Distance | Impact |
|---|---|---|---|
| 155S | DSTPPPG[T/S]TRVRAMAI | 0 |
direct
|
| 155N | DSTPPPG[T/N]TRVRAMAI | 0 |
direct
|
| 155A | DSTPPPG[T/A]TRVRAMAI | 0 |
direct
|
| 155I | DSTPPPG[T/I]TRVRAMAI | 0 |
direct
|
| 155P | DSTPPPG[T/P]TRVRAMAI | 0 |
direct
|
External references
dbSNP:
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